Areas of Activity
Investigation of the B cell repertoire in health and disease: a potential source for novel biomarkers
Recent advances in high-throughput DNA sequencing technologies have made possible to investigate the repertoire of antigen-specific B cell receptors at an unprecedented depth. Using the Ion Torrent deep-sequencing technology, we investigate at high-depth the shaping of the B cell repertoire of human donors and transgenic humanized rats exposed to diverse viral, bacterial and chemically-defined antigens. The objective of the project is the identification of antigen-specific public (i.e. convergent) signatures on the B cell repertoire that could be used as novel biomarkers for particular diseases and/or to retrospectively reconstruct immune challenges.
Analyzing millions of immunoglobulin sequences require a lot of computational power and extensive bioinformatics skills. We are seeking for collaborators able to provide support with the bioinformatics analyses of the sequences generated by our group. This implies the development of bioinformatics tools / software for data mining and visualization.