Business meets Research 2015
Axel Dubois / organization
Luxembourg Institute of Health
Esch-sur-Alzette, Luxembourg
Axel Dubois, PhD student
Profile last updated on 27 May 2015, 08:38
Axel Dubois / organization
Luxembourg Institute of Health
Luxembourg, Esch-sur-Alzette
Axel Dubois, PhD student

About Us


Areas of Activity

  • Life Sciences, Health, biotechnical, pharmaceutical industry

Organisation

Luxembourg Institute of Health

Country

Luxembourg
City: Esch-sur-Alzette

Type

R&D Institution

Participating in

09:00-13:00 Fri INNOVATION MATCHMAKING
Cooperation Request…
Investigation of the B cell repertoire in health and disease: a potential source for novel biomarkers

Investigation of the B cell repertoire in health and disease: a potential source for novel biomarkers

Request

Recent advances in high-throughput DNA sequencing technologies have made possible to investigate the repertoire of antigen-specific B cell receptors at an unprecedented depth. Using the Ion Torrent deep-sequencing technology, we investigate at high-depth the shaping of the B cell repertoire of human donors and transgenic humanized rats exposed to diverse viral, bacterial and chemically-defined antigens. The objective of the project is the identification of antigen-specific public (i.e. convergent) signatures on the B cell repertoire that could be used as novel biomarkers for particular diseases and/or to retrospectively reconstruct immune challenges.

SOLUTION OR EXPERTISE SOUGHT

Analyzing millions of immunoglobulin sequences require a lot of computational power and extensive bioinformatics skills. We are seeking for collaborators able to provide support with the bioinformatics analyses of the sequences generated by our group. This implies the development of bioinformatics tools / software for data mining and visualization.

Type

Request

Date

May 11, 2015